The investigators reported that in skin inflammation lesions, leaf extract inhibited macrophage-derived chemokine (MDC/CCL22) production via the downregulation of (STAT) 1 and extracellular signal-regulated kinase 1/2 (ERK1/2) pathways and, hence, improved several symptoms (ear edema and lymph node size) change in blood parameter (serum IgE) and histological changes in mice with allergic dermatitis. Here, CCL22 is linked to atopic eczema.