PRKN and Parkinson disease: The major pathogenic genes of PD include leucine-rich repeat kinase 2 (LRRK2), α-synuclein (SNCA), Parkin RBR E3 ubiquitin protein ligase (PRKN), PTEN-induced putative kinase 1 (PINK1), DJ-1 (Parkinsonism associated deglycase, PARK7), vacuolar protein sorting-35 (VPS35), and Glucosylceramidase (GBA) [14].