SPECC1 and infection: Another advantage of this system is that it relies on in situ detection of nsp5 proteolytic activity, which is highly specific to SARS-CoV(−2) infection, in contrast to other cell-based protocols relying on indirect and/or late impacts of infection, such as the measure of syncytia formation (Buchrieser et al., 2020) or of cell mortality (Riva et al., 2020; Belouzard et al., 2022; Chiu et al., 2022).