Zymosan from the fungal cell wall promotes the proliferation of oral squamous cell carcinoma (OSCC) cells through the TLR2/MyD88/NF-κB signaling pathway. Moreover, zymosan can promote the expression of E-cadherin, enhance the adhesion of C. albicans to OSCC cells, and further increase IL-1β production in OSCC cells, and promote cancerous inflammation. This evidence concerns the gene MYD88 and oral cavity squamous cell carcinoma.