Studies in the context of dengue infection have yielded similarly conflicting findings (Djamiatun et al., 2011; Sharma et al., 2016; Posadas-Mondragón et al., 2020), while TLR4 polymorphisms D299G and T399I were associated with COVID-19 severity and cytokine storm (Taha et al., 2021). The gene discussed is TLR4; the disease is COVID-19.