Although we have focused our investigation on eCIRP/TREM-1 activation of endothelial cells and their potential contribution to AKI, eCIRP may also promote AKI by acting on other renal cells known to express TREM-1 such as renal mesangial cells (Zhao et al., 2018), tubular epithelial cells (Maiese et al., 2019; Pan et al., 2021), and kidney macrophages (Campanholle et al., 2013; Zhang et al., 2019a; Zhang et al., 2019b). The gene discussed is TREM1; the disease is acute kidney injury.