TREM-1 activation has long been studied as a player in the dysregulated immune response in sepsis and, in its soluble form, is also predictive of sepsis severity, mortality, and development of sepsis-induced AKI (SA-AKI) (Derive and Gibot, 2011; Su et al., 2011; Brenner et al., 2017; Jedynak et al., 2018). This evidence concerns the gene TREM1 and Sepsis.