Primarily expressed in the basal epithelial cells of the nasopharynx and the large airways, AQP3 has been associated with Diffuse Alveolar Damage (DAD) and Acute Respiratory Failure (ARF) in humans (Pires-Neto et al., 2016) and shown to play a role in the triggering of inflammatory response in the lungs in ovalbumin-induced murine asthma (Ikezoe et al., 2016). The gene discussed is AQP3; the disease is respiratory failure.