The minor presence of MCT1 and MCT4 transporters in SHR intestinal epithelium had already been described by other groups (Yang et al., 2019; Robles‐Vera et al., 2020), but we are the first to also identify reduced SMCT1 mRNA levels in this model of hypertension, demonstrating a limitation in the absorption of SCFAs by the reduced expression of three, out of the five, known direct intestinal SCFAs transporters (Dalile et al., 2019). Here, SLC5A8 is linked to Hypertension.