Further regulators of CD49f expression include positive regulation by Oct4 and Sox2 in mesenchymal stem/stromal cells (Yu et al., 2012) and negative regulation by KLF9 in glioblastoma stem cells, which is important for repressing CD49f expression and glioblastoma stemness (Ying et al., 2014). This evidence concerns the gene POU5F1 and glioblastoma.