YTHDC2 and breast carcinoma: To clarify the role of YTHDC2 in breast cancer, we knocked down the endogenous YTHDC2 expression by infecting MCF-7, SK-BR-3, MDA-MB-231, and MDA-MB-468 cells with lentivirus containing YTHDC2 shRNA (Figures 2(a) and 2(b)).