The results revealed that NXPH4 expression has positive correlations with TGFB1 (rho = 0.376, p = 7.11e − 14), VTCN1 (rho = 0.324, p = 1.77e − 10), LGALS9 (rho = 0.324, p = 1.89e − 10), HHLA2 (rho = 0.324, p = 1.75e − 10), PDCD1 (rho = 0.213, p = 3.49e − 05), CTLA4 (rho = 0.215, p = 2.84e − 05), and TIM3 (HAVCR2) (rho = 0.278, p = 5.22e − 08) in HCC (Figures 7(b)–7(h)), whereas NXPH4 expression was not correlated with LAG3, programmed cell death protein 1 ligand 2(PDCD1LG2), and T cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT). This evidence concerns the gene HHLA2 and hepatocellular carcinoma.