We found that the infiltration levels of TIICs have significant difference in different NXPH4 expression level groups in HCC, including NK cells, regulatory T cells (Tregs), B cells naïve, resting mast cells, M1 macrophages, M2 macrophages, monocytes, resting dendritic cells, and M0 macrophages. The gene discussed is NXPH4; the disease is hepatocellular carcinoma.