Similarly, the differential expression analysis of A3B in the different pathological stages (early stages: stages 0, I, and II; and advanced stages: stages III and IV) revealed significant differences in adrenal cortex carcinoma (ACC), bladder cancer (BLCA), cholangiocarcinoma (CHOL), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), and thyroid carcinoma (THCA) (Figure 1(b)). This evidence concerns the gene APOBEC3B and cholangiocarcinoma.