The univariate Cox regression analysis on OS showed that CMTM3 was a protective factor in ESCC, CHOL, KICH, and PRAD patients, as well as BLCA, LUAD, COADREAD, COAD, OV, ACC, CESC, DLBC, KIRC, ESCA, KIRP, LGG, MESO, LIHC, PAAD, READ, PCPG, SARC, TGCT, STAD, THCA, UVM, and GBMLGG, and a risk factor in ESAD patients (Figure 5(a)). This evidence concerns the gene CMTM3 and esophageal squamous cell carcinoma.