The univariate Cox regression analysis on OS showed that CMTM3 was a protective factor for ESCC, CHOL, KICH, and PRAD patients, while being a risk factor for BLCA, LUAD, COADREAD, COAD, OV, ACC, CESC, DLBC, KIRC, ESCA, KIRP, LIHC, LGG, MESO, PCPG, PAAD, READ, SARC, TGCT, STAD, THCA, UVM, GBMLGG, and ESAD patients. This evidence concerns the gene CMTM3 and esophageal squamous cell carcinoma.