CKLF-like MARVEL transmembrane domain containing 3 (CMTM3) is the main member of the chemokine-like factor family (CKLFS) and is also one of the chemokine-like factor genes located in a cluster on chromosome 16q22 [8], which is differentially expressed in various human malignant tumors and is directly linked to the malignant phenotype of cells. The gene discussed is CKLF; the disease is cancer.