The level of ANXA5 (cALD Z-score = 2.98 and AD Z-score = 4.79), which is associated with familial late-onset AD from whole exome sequencing, in the cerebrospinal fluid of AD patients increased proportionally with the severity of the disease state as Aβ accumulates, playing a protective role against Aβ toxicity (Zhang et al., 2019; Bartolome et al., 2020). The gene discussed is ANXA5; the disease is Alzheimer disease.