FOS and early-onset autosomal dominant Alzheimer disease: Up-regulation of c-Fos expression has been associated with apoptosis after intracerebral hemorrhage (Chen et al., 2015), kainic-acid induced seizures (Schreiber et al., 1993) and potentiation of c-Fos activity was shown to promote neuronal cell death in a mouse model of Alzheimer’s disease (Choi et al., 2019).