As proposed by Wu et al. [21], a TME risk model constructed with the tumor immune infiltration-related genes SERPINE1, CX3CR1, CD200R1, GBP1, IRF1, STAP1, LOX, and OR7E47P based on public databases can be used to predict the prognostic survival of LC patients. The gene discussed is SERPINE1; the disease is laryngotracheoesophageal cleft.