In this study, we identified 7 genes that can be used to construct a prognostic model for SCLC patients via bioinformatics approach, of which CXCL2, ENG, ARRB1, BMP1, IRF1, and CCL5 were prognostic protective factors and LCP2 was the only prognostic risk factor. The gene discussed is CXCL2; the disease is small cell lung carcinoma.