In fact, the differences in molecular spectra of MYCN-amplified RB1-proficient retinoblastomas compared with other retinoblastoma subtypes were very well marked at the epigenomic level, which affected a molecular network beyond CDKN2C. Epigenetic alterations are well-known cancer events with versatile impact on various stages of carcinogenesis, ranging from disruption of genomic stability to silencing of tumor suppressors and regulatory elements.32 Here, MYCN is linked to retinoblastoma.