MYCN and retinoblastoma: Analyses 1 and 2 were between MYCNARB1PRO retinoblastomas and the 2 main retinoblastoma subbranches (adjusted P < 0.05, MYCN vs. clusters 1 and 2), whereas analysis 3 was between branches 1 and 2 to filter out genes that were differentially expressed between the two (adjusted P > 0.1, cluster 2 vs. cluster 1; Supplemental Figs 3 and 5, Appendix 8).