In logistic regression analyses of the patients in the training cohort, age, T stage, N stage, PSA, primary Gleason score, and secondary Gleason score were all identified as independent predictors of the risk of bone metastasis in individuals with prostate cancer in univariate and multivariate analyses (Figures 1(a) and 1(b)). The gene discussed is KLK3; the disease is Familial prostate cancer.