However, the rhythmic pattern of clock genes also displayed tissue specificity: the MESOR of hepatic Rev-erbα revealed significant elevation after HF treatment compared with the Ctr group (P < 0.05, Figure 2A), while the amplitude of Cry2 was strikingly higher in the HF group than in the Ctr group in the WAT (P < 0.05, Figure 2B). This evidence concerns the gene CRY2 and hydrops fetalis.