Gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) are all hepatic enzymes whose elevated activity is associated with adverse changes in glucose and lipid metabolism; therefore, these enzymes are considered to be markers of inflammation and risk factors for insulin resistance and the development of T2DM (53, 54). This evidence concerns the gene GPT and type 2 diabetes mellitus.