Four were upregulated including GPI-anchored protein (GPI-AP) biosynthesis signaling pathway (mmu00563; Pigc, Pigk), tuberculosis [mmu05152; Atp6v0c, Fc receptor, IgG, low affinity IV (Fcgr4), nuclear transcription factor Y subunit alpha (Nfya)], Systemic lupus erythematosus [mmu05322; Fcgr4, histone H2B (Hist1h2bq)], and Phagosome (mmu04145; Atp6v0c, Fcgr4) (Figure 3), and one was downregulated protein processing in endoplasmic reticulum [mmu04141; Ppp1r15a, thioredoxin domain-containing 5 (Txndc5)] (Figure 3). The gene discussed is PIGC; the disease is systemic lupus erythematosus.