Haplotypes for polymorphic markers segregating with Ferguson‐Smith syndrome in non‐Scottish and Scottish families differ, suggesting that Ferguson‐Smith syndrome is not caused by a founder mutation, thus considered now as a digenic/multilocus disease5, 6 caused by loss of function mutations of Transforming growth factor, beta receptor I (TGFBR1) gene interacting with permissive variants at a second linked locus on the long arm of chromosome 9.7 This evidence concerns the gene TGFBR1 and multiple self-healing squamous epithelioma.