The cornerstone in this direction was the study by Johansen et al., in 2015, describing that IκBζ is a master regulator of psoriasis‐associated proteins such as CCL20, DEFB4, S100A7, IL‐8, IL‐19 and LCN2 in cultured human keratinocytes.18 This evidence concerns the gene NFKBIZ and psoriasis.