The dynamic between these cardiac and peripheral vascular effects of PTH may provide an explanation for the occurrence of hypertension or hypotension that is observed in associations with chronic excess of PTH in some patients.(57, 58) Another possible mechanism for hypertension may also be the cross‐talk between PTH signaling and the renin‐angiotensin‐aldosterone system(57) (Table 2). The gene discussed is REN; the disease is hypertensive disorder.