PFN2 and bacterial infectious disease: PFN2 plays a pivotal role in phagocytes for the restriction of intracellular bacteria, and is thought to form pores in targeted bacterial membranes: human individuals carrying PFN2 missense mutations are significantly more susceptible to bacterial infection (McCormack et al, 2017; Merselis et al, 2020); and PFN2 knockout mice have bacterial pathogens replicating and disseminating more deeply into their tissues (McCormack et al, 2015, 2016; McCormack & Podack, 2015).