It can also be seen from Table 1 that, as expected, Lep and AdipoQ were readily detectable in epididymal adipose tissue and there was a significant increase in Lep (286 ± 33% of control diet expression) and a decrease in AdipoQ (37.7 ± 7.3% of control diet expression) in obesity. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.