The expansion of adipose tissue stores in obesity, particularly visceral adipose tissue, leads to an imbalance of these opposing groups of peptides, such that the level of pro‐inflammatory and pro‐diabetic adipokines, such as TNF‐α and monocyte chemoattractant protein‐1 supersedes.4 The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.