A functional role for Ccl4 in promoting dysglycaemia is suggested by observations that Ccl4 inhibition in Leprdb/JNarl diabetic mice and high‐fat diet‐fed mice was associated with improved hepatic and muscle insulin sensitivity and delayed hyperglycaemia progression, and treatment of streptozotocin‐induced diabetic mice with anti‐Ccl4 antibodies increased islet cell proliferation and serum insulin levels, leading to improved plasma glucose control.32 Here, INS is linked to Hyperglycemia.