The miRs have been documented to be critical for prostate cancer development via oncogenic or anti-oncogenic effects.42 More specifically, a decrease of miR-187 expression was measured in the study conducted by Casanova-Salas et al. 13 Also, another study highlighted the diminished miR-187 expression in prostate cancer cells.43 CD276 overexpression linked to the poor prognosis of patients with prostatectomy cohorts.44 On the other hand, Zang et al. also observed the overexpression of CD276 in patients with prostate cancer,45 which was similar to our findings. Here, CD276 is linked to Familial prostate cancer.