To address this hypothesis, the present study aimed to explore the exosomal communication within the prostate cancer microenvironment using hBMSCs, as well as the specific mechanism of hBMSC-derived exosomal miR-187 in prostate cancer cell growth and metastasis via the CD276/JAK3-STAT3-Slug axis. The gene discussed is JAK3; the disease is Familial prostate cancer.