Additionally, Exo or Exo-NC-agomir increased the expression of miR-187, E-cadherin and Bax and decreased that of CD276, Bcl-2, and JAK3-STAT3-Slug pathway-related genes in tumor tissues; compared with Exo-NC-agomir, Exo-miR-187 agomir further elevated the expression of miR-187, E-cadherin and Bax but diminished that of CD276, Bcl-2, and JAK3-STAT3-Slug pathway-related genes; Exo-miR-187 agomir + oe-CD276 rescued the effects of Exo-miR-187 agomir (Figure 7e-f and and Supplementary Figure S1G). Here, JAK3 is linked to neoplasm.