The results depicted that the volume and weight of tumor as well as the number of pulmonary metastatic nodules were diminished in nude mice treated with Exo or Exo NC-agomir, and a more pronounced reduction was noted following treatment with Exo-miR-187 agomir; however, Exo-miR-187 agomir + oe-CD276 abolished this reduction (Figure 7a-d). The gene discussed is CD276; the disease is neoplasm.