A previous study has documented that CD276 can accelerate the cell metastasis by activating the JAK-STAT signaling pathway in multiple myeloma cells.35 Immunoblotting revealed that after overexpression of miR-187 in PC-3 cells, the expression of Ki-67, Bcl-2, JAK3, p-STAT3, Slug, N-cadherin, Fibronectin, and MMP2 was reduced, while that of Bax and E-cadherin was elevated (Figure 4h-i and Supplementary Figure S1D-E). Here, JAK3 is linked to AL amyloidosis.