KMT2A and leukemia: As shown in Fig. 7c, SISU-102 clearly inhibited the expression of the HSF1 targets, HSP90 and SDHC, and HSF1 itself, in a dose-dependent manner and strongly suppressed the growth and OCRs of murine MLL-AF9 Hsf1fl/flcreER leukemia cells and human MV4–11 and NOMO-1 AML cells (Fig. 7d, e).