CD34 and acute myeloid leukemia: Importantly, the very low levels of HSF1 protein observed in non-malignant human BM biopsy specimens compared to human AML samples, mouse xenograft experiments using HSF1 knockdown human BM CD34+ HSPCs, and inhibition of HSF1 function with SISU-102 further support the idea that HSF1 is not required for human HSPC self-renewal.