ALDOB and glioblastoma: Furthermore, we found that fructose administration promoted growth of tumors derived from U87 cells, but this effect was not observed in tumors derived from U87 cells with knockdown of SLC2A5 or ALDOB (Supplementary Figs. 4f, 5b), suggesting that fructose-promoted GBM growth depends on GLUT5 and ALDOB.