Consistently, GBM cells with disruption of CARE motifs located within the promoters of SLC2A5 or ALDOB (Supplementary Fig. 3d) failed to induce mRNA (Fig. 3c) and protein (Fig. 3d) expression of these genes, or increase fructose metabolic rate (Fig. 3e) and fructose consumption (Fig. 3f) upon glucose deprivation. The gene discussed is ALDOB; the disease is glioblastoma.