The Pan-Cancer analysis showed that CHMP4C to be up-regulated in breast cancer, colon adenocarcinoma, liver hepatocellular carcinoma, lung adenocarcinoma, and other malignant tumors (Fig. 10A, B), and the Kaplan–Meier analysis shows that CHMP4C may be a risk factor for lung adenocarcinoma, pancreatic ductal adenocarcinoma and thymoma, moreover, univariate Cox analysis showed that CHMP4C could be used as an independent prognostic factor (Additional file 3: Fig. S1H). Here, CHMP4C is linked to breast cancer.