INS and Insulin resistance: There were otherwise no significant differences between the groups in three additional measures of baseline-adjusted beta-cell function at 8-weeks (insulinogenic index/HOMA-IR; ΔCpeptide0-120/Δgluc0-120 × Matsuda index; ΔISR0-120/Δgluc0-120 × Matsuda index), or in baseline-adjusted insulin sensitivity (Matsuda index) or insulin resistance (HOMA-IR).