Labernadie et al. showed that the mechanical force applied by the heterotypic interactions of E-cadherin/N-cadherin can coordinate invasion between CAFs and tumor cells via two kinds of complex mechanisms: CAFs may enhance the invasiveness of cancer cells by taking them away from the tumor, and cancer cells further boost their spread by directing CAF migration away from the tumor [78]. The gene discussed is CDH1; the disease is neoplasm.