A second model to predict the incidence of MACE based on serum HMGB-1 levels and traditional cardiovascular risk factors (sex, age, diabetes duration, BMI, smoking status, hypertension, previous CAD and CVD history, treatment, total cholesterol, LDL cholesterol, triglycerides, fasting blood glucose (FBG), HbA1c) was made. The gene discussed is HMGB1; the disease is hypertensive disorder.