There were no differences between patients with MALE and without MALE in terms of age (p = 0.19), sex (p = 0.40), BMI (p = 0.63), diabetes duration (p = 0.77), history of high blood pressure (p = 0.62), hypercholesterolemia (p = 0.31), history of CAD (p = 0.56), history of CVD (p = 0.53), antidiabetic oral medications (p = 0.95) and insulin (p = 0.06), LDL-C levels (p = 0.61), ABI (p = 0.88), Rutherford category (4 p = 0.68, 5 p = 0.68), glycated hemoglobin levels (p = 0.10) and renal function (p = 0.95). This evidence concerns the gene INS and Hypercholesterolemia.