HMGB1 and peripheral arterial disease: After adjustment for traditional cardiovascular risk factors, a multivariable analysis was elaborated, showing that ABI (p = 0.001, 95% CI 0.417, 1.549) and HMGB-1 serum levels (p < 0.000, 95% CI 0.082, 0.131) were independent risk factors for MACE in patients with PAD who underwent LER (Table 3).