Mature DCs enriched in immunoregulatory molecules (mregDCs), co-expressing immunoregulatory genes (Cd274, Pdcd1lg2, and Cd200) and maturation genes (Cd40, Ccr7, and Il12b), can uptake tumor antigens, upregulate IL-12 in an IFNγ-dependent manner, and initiate effector T cells response [44]. Here, IFNG is linked to neoplasm.