Emerging evidence has suggested that oxidative stress in the skin is a key cause of cellular senescence, consequently leading to skin aging.23, 24 Previous studies have elucidated that aging and ultraviolet B (UVB) exposure are strongly correlated with the high risk of skin cancer.25, 26 It is suggested that an increased presence of senescent fibroblasts in geriatric skin causes the silencing of insulin-like growth factor 1 (IGF-1) expression in the skin.27 The gene discussed is IGF1; the disease is skin neoplasm.