Cellular senescence in the skin leads to skin aging which can be induced by both extrinsic and intrinsic factors.2, 3 Senescent cells can be detected with many hallmarks, such as enhanced activity of senescence-associated β-galactosidase (SA-β-gal), elevated levels of tumor suppressor p53, cyclin-dependent kinase (CDK) inhibitor p21 and senescence marker protein 30 (SMP30).4, 5 Numerous studies have indicated that oxidative stress contributes to skin aging and dermal damage.6 Here, RGN is linked to aging.