The HDACi-mediated inhibition of PARylation by Rom was also observed in PEER (T-cell acute lymphoblastic leukemia: T-ALL), Toledo (diffuse large B-cell lymphoma), and RPMI8226 (multiple myeloma) cells, suggesting a universal effect across various hematologic cancer cell lines (Figure 1C). The gene discussed is ROM1; the disease is T-cell acute lymphoblastic leukemia.