CircPOK increased the IL6 transcript by combining with ILF2/3 to occupy the promoter of IL6 [16]; The circIMMP2L regulated epigenetic remolding in esophageal squamous cell carcinoma by inducing CtBP1 nucleus retention [17]; The circACC1 up-regulated the glycolysis and β-oxidation by ensuring the stability of AMP-activated protein kinase (AMPK) protein [18]; The circVAMP3 negatively regulated hepatocellular carcinoma (HCC) mediated by cell cycle-associated protein 1 (CAPRIN1) and Stress Granule Assembly Factor 1 (G3BP1) interaction-dependent phase separation [19]. This evidence concerns the gene IL6 and esophageal squamous cell carcinoma.