Among these genes, 30 commonly mutated driver genes were found in at least 5 pGI-DLBCL patients, including TP53, P2RY8, KMT2D, MUC16, CSMD3, FAT4, CCND3, HIST1H1C, CARD11, MYC, LRP1B, B2M, TET2, FOXO1, EBF1, BTG1, SETD1B, BCR, COL3A1, DDX3X, AHNAK2, PIM1, ID3, DNM2, PTPN6, FAT1, ROBO2, NFKBIA, BCL7A, SGK1. Next, we used those potential driver genes shared by at least 2 pGI-DLBCL patients to perform gene clustering analysis with the aid of DAVID algorithm. The gene discussed is TP53; the disease is diffuse large B-cell lymphoma.