Furthermore, mutation frequencies of MUC16 (10/53), CSMD3 (10/53), RYR2 (10/53), FAT4 (9/53), TET2 (7/53), EBF1 (7/53) and SETD1B (7/53), which functions at the transcriptional regulation, epigenetic modification or either cellular attachment, were also increased compared to those in common DLBCL according to COSMIC database. The gene discussed is TET2; the disease is diffuse large B-cell lymphoma.