At the transcriptome level, the results of expression analysis of multiple cohorts, including TCGA LIHC dataset, GSE14520 dataset, GSE76427 dataset, and GXMU cohort, all consistently suggested that the expression of MCM2 in HCC tissues is significantly higher than that of liver tissues (Fig. 1a–d). The gene discussed is MCM2; the disease is hepatocellular carcinoma.