The KEGG pathway enrichment analysis of the differential genes indicated that MCM2 is involved in the p53 signaling pathway, cell cycle, and hippo signaling pathway (Fig. 4b); Moreover, hepatocellular carcinoma (hsa05225) appeared in the results of the enrichment analysis, indicating that MCM2 plays a key role in the development and progression of HCC (Fig. 4b). Here, TP53 is linked to hepatocellular carcinoma.