Consistently with previous data showing that loss of Ambra1 promotes an epithelial-to-mesenchymal (EMT)-like phenotype in melanoma [29], re-expression of the L110F and P170S also improved expression of the mesenchymal markers Fibronectin (FN1) (Fig. 5F) and Vimentin (VIM) (Fig. 5G) at mRNA and of CDH2, VIM and SNAI1 at protein (Fig. 5H; Supplemental Fig. 2I-K) level, whereas a reduced protein expression was observed for the epithelial marker CDH1 (Fig. 5H; Supplemental Fig. 2L). The gene discussed is CDH1; the disease is melanoma.