AMBRA1 and neoplasm: More recently, the role of AMBRA1 as tumor suppressor has been further extended, as by its regulation of cell cycle by Cyclin D1 stabilization (via interaction with the E3 Ubiquitin ligase DDB1-Cullin4) [26–28] and of malignant invasiveness (through focal adhesion kinase FAK1 hyperactivation) [29].