However, when focused on these categories in detail by looking into the function annotations, we found that the lost SEs associated genes after the restoration of CASZ1b are enriched in regulating “cell proliferation of tumor cell lines” (Supplementary Fig. 3D, top panel), which includes cell cycle regulators CCND1 and CDK6 that are known growth regulators in NB [46, 47]. The gene discussed is CCND1; the disease is neuroblastoma.