By focusing on the SEs that drive the CRC components and neural crest lineage specifiers, we observed that the restoration of CASZ1 resulted in a decrease of SEs signals (H3K27ac signals) on a subset of these TFs, including GATA2, GATA3, ISL1 and TBX2 (Fig. 6F, Supplementary Fig. 3E). The gene discussed is GATA3; the disease is colorectal carcinoma.