Among these hub genes, 13 genes, including NCF2, FGR, ITGAL, CXCL10, LILRB2, FCGR2B, PECAM1, CD163, ITGAM, SIGLEC1, ITGAX, ITGB2 and S100A8, were significantly associated with inferior OS of AML patients (Supplementary Fig. S4). The gene discussed is CD163; the disease is acute myeloid leukemia.