Rusiniak E, et al. previously reported that TNFAIP2 was downregulated in acute promyelocytic leukemia (APL) and could be induced by retinoic acid (RA) in PML-RARα-positive cells, suggesting that TNFAIP2 was involved in RA signaling in APL [45]. This evidence concerns the gene TNFAIP2 and acute promyelocytic leukemia.