Because TNFAIP2 expression was upregulated in AML patient samples and associated with poor survivals, we explored the biological role of TNFAIP2 in AML by establishing stable TNFAIP2 knockdown AML cell lines THP-1 and U937 cell lines via lentivirus infection. This evidence concerns the gene TNFAIP2 and acute myeloid leukemia.