Among these hub genes, 13 genes, including NCF2, FGR, ITGAL, CXCL10, LILRB2, FCGR2B, PECAM1, CD163, ITGAM, SIGLEC1, ITGAX, ITGB2 and S100A8, were significantly associated with inferior OS of AML patients (Supplementary Fig. S4). Here, ITGAM is linked to acute myeloid leukemia.