As for DNA methylation, we observed an obvious association between increased DNA methylation level at gene-body region and high expression of TNFAIP2. Nevertheless, there was no correlation between promoter DNA methylation and mRNA level of TNFAIP2. In general, cancer cells are characterized by two major alterations of DNA methylation: global DNA hypomethylation while gene-specific DNA hypermethylation of promoter-associated CpG island. This evidence concerns the gene TNFAIP2 and cancer.