The present study showed multifaceted prognostic effect of TNFAIP2 overexpression on OS in certain types of cancers based on TCGA and GEO database, supported by an association with high expression of TNFAIP2 and better OS in STAD, BLCA, SARC, and SKCM whereas inferior OS in AML, KIRC, UVM, LGG, THYM,DLBCL, meningioma and lung adenocarcinoma. The gene discussed is TNFAIP2; the disease is acute myeloid leukemia.