TP53 and metastatic malignant neoplasm in the lymph nodes: Previously, all poorly differentiated PCs analyzed by Marinescu et al. (2016) were p53 positive [82], and Lopes et al. (2002) found that p53 expression was an independent factor for lymph node metastasis (relative risk 4.8, 95% CI 1.6 to 14.9); the 5 and 10-year overall survival rates were 65.2% and 54.6% in PCs with negative p53, and 30.2% and 26.4%, respectively, in those with positive p53 [18].