In addition, allergic conjunctivitis, which is generally associated with AR, was found in 66.6% of the patients included in the study, while this rate decreased to 17.6% after six weeks of treatment Nikakhlagh et al. used 0.5 mL of Nigella sativa oil was for four weeks in their study; and no significant difference was found in total serum IgE levels in the study group, but a significant reduction in symptoms was observed in patients with AR symptoms (e.g., itching, nasal congestion, sneezing, and nasal discharge).18 The gene discussed is IGHE; the disease is atopic conjunctivitis.