RORC and experimental autoimmune encephalomyelitis: However, conditional deletion of Rorc (gene for RORγ and RORγt) in IL-17A-producing effector Th17 cells revealed RORγt to be essential for maintenance of Th17 cells, but not for development of immunopathology during experimental autoimmune encephalomyelitis (EAE) (Brucklacher-Waldert et al., 2016).