In 2020, the SRSF2 mutation positivity has been incorporated in the prognostic scoring systems-MIPSS-PV, as an independent genetic risk factor in PV, together with age > 67 years, leukocyte count ≥ 15G/L, and previous thrombosis (Tefferi et al. 2020). The gene discussed is SRSF2; the disease is acquired polycythemia vera.