Herein, we present the results of our study evaluating the impact of the factors postulated to be associated with PV occurrence, manifestation and outcome, including the SNVs’ genotypes (JAK2 rs12343867, TERT rs2736100, OBFC1 rs9420907, miR-146a rs2431697) and non-driver genetic variants (SRSF2, ASXL1, U2AF1, IDH1, IDH2). The gene discussed is SRSF2; the disease is acquired polycythemia vera.