The results revealed that, compared with subjects in the lowest quartile (Q1), those in high quartiles (Q2–Q4) were all found to have a higher risk of increased arterial stiffness (Q2 vs. Q1: odds ratio (OR):1.54, 95% CI: 1.05 to 2.27, P = 0.029; Q3 vs. Q1: OR: 1.57, 95% CI: 1.06 to 2.33, P = 0.026; Q4 vs. Q1: OR: 2.23, 95% CI: 1.50 to 3.30, P < 0.001) after adjusting for age, sex, obesity, diabetes, hypertension, dyslipidemia, hyperuricemia, hs-CRP level, cigarette smoking, and regular exercise. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.