ANXA5 and colonic neoplasm: GBEVs are absorbed by colon cancer cells (HCT116, SW1116, and SW620 cells) and significantly inhibit colon cancer cell proliferation, migration, and invasion in a concentration-dependent manner.108L. paracasei EVs (200 μg/mL), upon co-incubation with colon cancer cells for 48 h, significantly promote their apoptosis, as determined using Annexin V/PI double staining.