Kim et al. injected E. coli BL21 and E. coli W3110 msbB-mutant-derived EVs (msbB, the gene encoding lipid A acyltransferase) into the tail vein of colon adenocarcinoma CT26 mice and found that GBEVs could be specifically targeted and enriched in tumor tissue, with extended anti-tumor activity by inducing massive IFN-γ production and promoting T-cell-mediated immune responses. This evidence concerns the gene IFNG and neoplasm.