The 11 genes that were significantly up-regulated in the host macrophages infected with the MKR at 4 hr post-infection compared with that of 0 hr post-infection chosen for the qRT-PCR analyses were ALKAL1, MUC20, MAP3K4, NUPR1, RAB42, RGI3, SMIM25, SNAI1, TRAF2, TRIM63, and PMAIP1. The gene discussed is PMAIP1; the disease is infection.