SETBP1 and cancer: Mahmoodzadeh et al. used PDAC-derived sEVs as carriers to load staphylococcal enterotoxin B (SEB), which was used as a potent immune stimulator for T cell activation.[154] They demonstrated that SEB-loaded sEVs could significantly induce cancer cell apoptosis and no cytotoxic effect was observed in both human kidney embryonic cells and peripheral human white blood cells, indicating that such a strategy might be used to stimulate an immune response against PDAC cells.