The commercial available assay ExoDx Prostate (IntelliScore) (NCT03235687, NCT03031418, NCT04720599, NCT02702856) is based on the detection of three RNAs (PCA3, SPDEF, ERG) in urinary sEVs from prostate cancer patients by quantitative reverse transcription-polymerase chain reaction (RT-PCR). This evidence concerns the gene SPDEF and Familial prostate cancer.