Similarly, sEVs derived from cancer cells carrying immunosuppressive molecules such as Fas ligand (FasL), TNF-related apoptosis-inducing ligand (TRAIL), programmed death-ligand 1 (PD-L1), and enzymes engaged in the adenosine pathway (CD39 and D73) were found to mediate the functions of immune cells, such as activation of regulatory T-cells (T regs), DCs, macrophages and immature myeloid-derived suppressor cells (MDSCs) (Fig.5), thus playing important roles in the establishment of an immunosuppressive microenvironment.[191–193]. Here, TNFSF10 is linked to cancer.