To study the roles of glycan changes in pancreatic diseases, Engle et al. inducibly expressed human fucosyltransferase 3 and β-1,3-galactosyltransferase 5 in mice to reconstitute the glycan sialyl-Lewisa (also known as CA19-9) which was a carbohydrate antigen attached to O-glycans on the surface of pancreatic cells. This evidence concerns the gene FUT3 and pancreas disorder.