EGF and cancer: Cancer-derived sEVs play key roles in PDAC progression and in the onset of cancer drug resistance.[35] It has also been reported that cancer-derived sEVs can transport epidermal growth factors to macrophages, thus interfering with the innate immune system’s function.[157] These cancer-derived sEVs not only promoted the cancer development, but also affected the immune system and drug resistance in order to protect the cancer cells.